Product Overview – OsteoBoost

The Osteoboost kit contains the apparatus required to harvest osteoprogenitor cells from a patient’s bone marrow and to combine and distribute those cells throughout the porous structure of an osteoconductive material such as Orthos’ βGran, a synthetic osteoconductive scaffold product for use in the treatment of osseous defects which can occur as a result of trauma or in skeletal defects created surgically. The Osteoboost kit provides the surgeon with a convenient, minimally invasive method of harvesting osteoprogenitor cells by aspirating autologous bone marrow and combining it with βGran synthetic osteoconductive scaffold.

Osteoboost harvest kits were developed to complement the βGran product range  . Most operating theatres, where bone grafting procedures take place, do not have the apparatus required to harvest bone marrow stem cells. Furthermore the bone marrow aspiration apparatus available is mainly used by haemotologists in the treatment of leukemia and is not designed to provide the large volumes of cells that are required for bone grafting.



Osteoboost provides all of the apparatus required. The result is a convenient, simple to operate, single use and sterile kit.

Clinical data exists in the literature which clearly demonstrates the benefit that adding osteoprogenitor cells from the patient’s bone marrow has on the healing around an osteoconductive bone substitute. Adding marrow stem cells to βGran greatly enhances the efficiency of the material as demonstrated in pre-clinical studies. Harvesting cells directly from the patient at the time of surgery prevents any possibility of adverse reactions.

Osteoboost Design features

Ergonomic Handle

The company worked with haemotologists who regularly perform large numbers of marrow aspiration procedures for the treatment of leukemia and other diseases. Their first request was for a cannula with a larger, more ergonomic handle to give greater control in placement. Orthos designed the handle of the Osteoboost Cannula with that in mind and to be more ergonomic than any product currently available. The offset cannula position, combined with the large ovoid shape, fits naturally into the hand giving greater “feedback” to the user and therefore more control.

Low vacuum chamber

The modified syringe incorporates a simple-to-use, low-vacuum chamber into which osteoconductive bone graft, such as βGran, can be easily placed prior to aspirating cells directly into the chamber. These cells are then simultaneously distributed throughout the 3-dimensional structure of the βGran. The resulting composite material has been shown to provide superior bone repair and additional bone formation compared to using the synthetic graft alone.

Additional side-wall holes

Muschler and his co-workers demonstrated that cell concentrations fall if a large volume of marrow is aspirated from a single site due to a higher volume of blood being drawn into the cannula. Osteoboost has 3 additional side-wall holes spaced at 5mm intervals along the distal 15mm of the cannula. Each side-wall hole is positioned at 45° intervals around the circumference. One effect these additional side-wall holes have is to dramatically increase the area from which the marrow sample is being collected. The layout of the holes draws marrow from a 90° sector 15mm high rather than through a single hole in the end of the cannula. They also reduce the pressure required to draw the sample which reduces the friction placed on the cell wall thereby preventing rupture of the cell, leading to a higher number of viable cells being harvested. The protocol for using Osteoboost includes rotating the cannula through 90° intervals which enables the user to collect multiple aliquots without compromising the cell concentration.

Large internal diameter cannula

To further reduce the forces being exerted on the cells during aspiration a rigid, wide bore tubing has been used. This achieves a larger internal diameter 3mm rather than 2.2mm with standard tubing. As a result fewer cells are ruptured during aspiration, increasing the viability of an already higher population of cells. This means the system is highly efficient.



4-facet diamond point trocar

A highly polished 4-facet diamond point trocar tip provides easy, non-traumatic passage through the soft tissues. Once the bone cortex is reached the tip acts as an ‘awl’ achieving simple penetration of the cortex exposing the cancellous bone and the rich source of cells below.